Vector-based genetically modified vaccines: Exploiting Jenner’s legacy

Vaccines Made from Genetically Modified Organisms

Genetically modified live attenuated parasites as vaccines for leishmaniasis.

Leishmaniasis causes significant morbidity and mortality worldwide and is an important public health problem. Even though it is endemic in developing countries in tropical regions of the world,in recent years economic globalization and increased travel has extended its reach to people in developed countries. Leishmania is usually spread by the bite of the female sandfly. In addition, naïve popu...

Viral vector-based influenza vaccines

Antigenic drift of seasonal influenza viruses and the occasional introduction of influenza viruses of novel subtypes into the human population complicate the timely production of effective vaccines that antigenically match the virus strains that cause epidemic or pandemic outbreaks. The development of game-changing vaccines that induce broadly protective immunity against a wide variety of influ...

Therapeutic vaccines based on genetically modified Salmonella: a novel strategy in cancer immunotherapy.

In the course of evolution, bacteria from the genus Salmonella adapted to survive and multiply in a vertebrate host. Skillful use of bacterial interactions with the host immune system became the basis for the development of modified Salmonella-based therapeutic vaccines. Bacterial genome can be modified to reduce toxicity and to develop or enhance therapeutic activity. Salmonella-based therapeu...

Pathogen evolution issues in genetically modified mosquito vector strategies

In this paper, pathogen evolution will not be considered in the extended concept of adaptation through mutability, heredity and long-term adaptation through speciation. In contrast, the main issues deal with aspects related to polymorphism and population diversity that arise by selection processes and how these may influence vector– pathogen–human relationships. Three aspects related to these r...